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Associate Director, Antibody Engineering

Weill Cornell Medical College

New York, NY
Weill Cornell Medical College
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Job Details

Position Summary

Leads efforts in the design and engineering of antibody and antibody\-based therapeutics for the Tri\-Institutional Therapeutics Discovery Institute \(Tri\-I TDI\), a partnership of Memorial Sloan Kettering Cancer Center, the Rockefeller University, and Weill Cornell Medicine\. Supports exploratory and advanced projects across the biologics discovery portfolio through format design and optimization of biologic drug properties\.

Job Responsibilities

+ Establishes a laboratory for antibody engineering to support the biologics discovery portfolio\.

+ Identifies, defines and implements processes for design and optimization of antibody\-based scaffolds including bi\-specifics and antibody\-drug conjugates \(ADCs\), and drug properties of lead molecules to support progression of projects across the portfolio\.

+ Oversees the daily operations of the antibody engineering team, including sequence and structure\-based analysis and modeling, sequence optimization, affinity maturation, humanization, sequence de\-immunization and antibody stabilization\.

+ Collaborates with the principal investigators at the academic institutions to identify and generate therapeutically relevant formats and optimize drug properties\.

+ Recruits and manages technical support staff\.

+ Provides technical training as needed in all aspects of antibody engineering\.

+ Manages projects from the biologics discovery portfolio in close collaboration with the industry partner and the principal investigators at the academic institutions\.

+ Keeps current with literature and emerging trends in the discipline\.

+ Submits progress reports and presents project updates at meetings with the principal investigators and the Tri\-I TDI leadership team\.


+ PhD in related field


PhD degree in biochemistry, molecular biology, structural biology, or related field\.

A minimum of 5 years of experience working in antibody engineering, preferably in the pharmaceutical or biotechnology industry\.

Experience in biologics drug discovery and pre\-clinical development\.

Demonstrated track record with publications or patents\.

Expertise in project planning and management\.

Experience in the design and production of multi\-specific antibodies\.

Knowledge in generating antibody\-drug conjugates\.

Proficiency in antibody and protein modeling using Schrdinger, Rosetta, or similar tools\.

Knowledge, Skills and Abilities

+ Critical independent thinking, prioritization of tasks, strong problem\-solving, and excellent communication skills

+ Timely delivery of team goals and ability to build productive relationships with colleagues, collaboration partners, and stakeholders

+ In\-depth knowledge of state\-of\-the\-art technologies and methods for functional assay development and screening of antibodies

Licenses and Certifications

Working Conditions/Physical Demands

Weill Cornell Medicine is a comprehensive academic medical center that's committed to excellence in patient care, scientific discovery, and the education of future physicians in New York City and around the world\. Our doctors and scientists\-faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization\-are engaged in world\-class clinical care and cutting\-edge research that connect patients to the latest treatment innovations and prevention strategies\. Located in the heart of the Upper East Side's scientific corridor, Weill Cornell Medicine's powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U\.S\. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria and Turkey\. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at NewYork\-Presbyterian Hospital/Weill Cornell Medical Center, NewYork\-Presbyterian/Lower Manhattan Hospital, and NewYork\-Presbyterian/Queens\. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients \- the center of everything we do\. Weill Cornell Medicine is an Equal Employment Opportunity/Minorities/Females/Vet/Disabled employer\.
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